Published on in Vol 9 (2025)

Preprints (earlier versions) of this paper are available at https://preprints.jmir.org/preprint/70737, first published .
Games to Improve the Clinical Skills of Nursing Students: Systematic Review of Current Evidence

Games to Improve the Clinical Skills of Nursing Students: Systematic Review of Current Evidence

Games to Improve the Clinical Skills of Nursing Students: Systematic Review of Current Evidence

1Department of Medical Education, School of Medical Education and Learning Technologies, Shahid Beheshti University of Medical Sciences, Tehran, Iran

2Department of Health Informatics, Smart University of Medical Sciences, Tehran, Iran

3Artificial Intelligence in Medical Sciences Research Center, Smart University of Medical Sciences, Tehran, Iran

4Department of Nursing, School of Nursing, Abadan University of Medical Sciences, Abadan, Iran

5School of Medicine, Azad University of Medical Sciences, Mashhad, Iran

6Department of Health Information Management, School of Allied Medical Sciences, Shahid Beheshti University of Medical Sciences, Tehran, Iran

7School of Medicine, Bushehr University of Medical Sciences, Bandar Būshehr, Iran

8Department of Medical Education, Smart University of Medical Sciences, No.3 1st Alley, Sarafraz St, Shaheed Beheshti St, Tehran, Iran

*all authors contributed equally

Corresponding Author:

Esmaeil Mehraeen


Background: As medical education evolves, incorporating innovative teaching methods is crucial for developing nursing students’ critical thinking and problem-solving skills. Game-based learning (GBL) has gained popularity, engaging students through immersive experiences and allowing personalized learning.

Objective: This systematic review aimed to investigate the impact of educational games on outcomes of clinical nursing skills.

Methods: In this study, the authors systematically searched the 4 public databases (PubMed, Embase, Scopus, and Web of Science) to investigate the role of educational games in improving the clinical skills of nursing students. This paper is based on the PRISMA (Preferred Reporting Items for Systematic Reviews and Meta-Analyses) 2020 guidelines. We also checked the bias risk of selected studies by the Newcastle-Ottawa Scale (NOS) bias assessment tool.

Results: In this study, 801 articles were initially retrieved using a specified search strategy, with 38 remaining after applying inclusion and exclusion criteria. The final included studies published between 2017 and 2023 spanned various countries and focused on diverse learning objectives. A broad range of learning objectives, such as developing diagnostic reasoning, enhancing knowledge and cognitive skills, and improving training methods, can be supported by a game-based platform. We also showed that while many games used web-based platforms, few were conducted in person, and some were developed in app formats for smartphones.

Conclusions: GBL is transforming nursing education by enhancing student engagement and clinical skills through immersive experiences. Despite its advantages, GBL faces challenges such as development costs and the effect of expertise reversal. Developing standardized assessment tools will help unify definitions and improve the comparability of research findings, ultimately enhancing the evidence base for GBL’s effectiveness.

Asian Pac Isl Nurs J 2025;9:e70737

doi:10.2196/70737

Keywords



As medical science and medicine advance daily and continuously influence medical education, health care, and nursing must constantly seek innovative teaching and learning methods [1-3]. Nurses are the frontline of medical care and constitute the largest segment of the global health workforce. Considering this, it is more than crucial for nursing students to receive a thorough education during their training, which can be provided through advanced evidence-based educational programs that keep pace with current changes in the field [4].

Currently, medical and nursing students are required to acquire advanced skills during their educational courses, including high levels of skills in critical thinking, problem-solving, and analysis, to pave the way toward developing higher-order thinking skills [1]. Nursing education encounters several challenges, including limited training time, which restricts the ability to provide effective practical learning experiences. These obstacles underscore the necessity for innovative strategies that can complement traditional educational methods and improve the overall quality of nursing education [5]. With the emerging role of technologies in this century, it is essential to incorporate active learning methods that go beyond traditional reading, listening, or watching, enabling students to explore and integrate knowledge actively to develop these levels of skills [1].

E-learning, web-based learning, computer-based simulators, mobile devices, virtual reality modalities, and games are a few of the various information technologies and educational methodologies that have been incorporated into nursing education due to technological advancements that we are witnessing in the current era, augmenting the traditional educational curricula [4]. Among the diverse modalities of technology-enhanced learning, games serve as exemplary tools for facilitating collaborative activities, review, and evaluation within the classroom setting. They introduce an element of enjoyment and maintain a clear educational objective, resulting in positive learning outcomes. Furthermore, microlearning (the process of acquiring knowledge through small chunks of information that can be delivered via videos, articles, ebooks, audio clips, etc) strategies contribute to enhancing the effectiveness of educational experiences [6].

The application of gamification within the education of health care professionals is experiencing rapid growth [7]. Gamification is a strategic approach to enhance engagement by integrating game elements into educational settings. This methodology aims to develop specific skills, establish objectives that imbue learning with meaning, actively involve students, optimize the learning process, facilitate behavioral change, and promote social interaction [8].

In nursing education, there has been a notable increase in the adoption of innovative teaching methods to adapt to the aforementioned issues. One such approach that is becoming increasingly and significantly popular is game-based learning (GBL) [1]. GBL incorporates games or game-like elements, concepts, mechanisms, or designs into education. This approach integrates educational games into classroom instruction and self-directed learning, offering students an immersive learning experience that enhances their acquisition of knowledge and skills [9]. This method consists of enabling students to learn through personal experiences via gaming perspectives and platforms and allows them to manage their learning according to their progress and capabilities [1].

GBL research often references three key terms: “serious game,” “educational game,” and “digital educational game.” These terms overlap, but differ in specific ways. A serious game refers to games designed with an educational purpose, rather than for entertainment. Educational games are games specifically designed for education, including both physical and digital formats. Narrowly defined, they are electronic games developed for learning, while broadly defined, they encompass traditional games, educational software, and toys that combine fun with learning objectives. In addition, digital educational games refer to educational games that require digital platforms and technology. They promote understanding of educational content and come in various types, such as adventure, role-playing, business, and logic games. These games can support both single-player and multiplayer formats. This concept can integrate fun with learning, enhancing the educational experience by leveraging technology to engage learners and improve their mastery of the subject matter [9].

These approaches support learning by integrating activities like feedback, testing, and spaced repetition with active participation, autonomy, and positive experiences for students, promoting a more effective educational environment [10]. According to the literature available surrounding this matter, students who have experienced GBL are more likely to achieve significantly better cognitive learning outcomes. GBL creates an atmosphere of high enthusiasm, active participation, and great enjoyment, and the fusion of these is more likely linked to improving learning results [11].

By fully engaging in an activity, one can achieve a state of intense focus, which can aid the learning process and lead to an optimal experience of learning. This state is referred to as “flow.” GBL encompasses physical games like board games and digital formats, including virtual reality. These educational models engage students with challenges that promote exploratory behavior, allowing them to actively solve problems and reflect on their actions, drawing on the concept of “flow” [1]. The affordances identified in GBL are consistent with the principles of flow theory. It is anticipated that as players engage with the game and refine their skills, the level of difficulty will progressively increase. Consequently, flow theory is used in game studies to foster concentration among students during lectures, based on these principles [12].

Although nurse educators have been slow to embrace this concept, research shows that game-based learning frequently outperforms traditional teaching methods [1,7]. In addition, the COVID-19 pandemic emerged as a cause to force higher education institutions to rapidly shift to virtual teaching and learning, which necessitated maintaining student engagement while ensuring that the content and methods stayed relevant to their future careers [7].

A recent systematic review supports these points and emphasizes the necessity for more research on the use of specific games among nursing students [1]. Identifying and analyzing the increasing number of published studies in this area is important to develop a comprehensive evidence base. This systematic review aims to identify studies on educational games in nursing education that enhance students’ skills, summarize their impacts on learning outcomes, and explore the concept of game-based learning in nursing.


Overview

In this study, the authors systematically searched the 4 public databases to investigate the role of educational games in improving the clinical skills of nursing students. This paper is based on the PRISMA (Preferred Reporting Items for Systematic Reviews and Meta-Analyses) 2020 guidelines (the PRISMA checklist is provided in Checklist 1). We also checked the bias risk of selected studies by the Newcastle-Ottawa Scale (NOS) bias assessment tool.

Data Sources

We searched the defined keywords in the databases of PubMed, Embase, Scopus, and Web of Science. The search was conducted on July 14, 2024, and all English-language studies were included in the screening. The PubMed search query and its combinations are as follows: (“games, experimental”[MeSH Terms] OR “gamification”[MeSH Terms] OR “game”[Title/Abstract] OR “gamification”[Title/Abstract] OR “educational game”[Title/Abstract] OR “serious game”[Title/Abstract]) AND (“Nurses”[MeSH Terms] OR “Nursing”[MeSH Terms] OR “Nurse Practitioners”[MeSH Terms] OR Nurses[Ti] OR Nursing[Ti] OR “Nurse Practitioners”[Title/Abstract]) AND (“Education”[MeSH Terms] OR “Education”[Title/Abstract] OR “Learning”[Title/Abstract] OR “Nursing education”[Title/Abstract] OR “Clinical skills”[Title/Abstract] OR “Virtual reality”[Title/Abstract] OR “Virtual learning”[Title/Abstract] OR “Virtual education”[Title/Abstract] OR “Virtualization”[Title/Abstract]). Similar structured queries were applied in Embase, Scopus, and Web of Science, adjusted for each database’s indexing system (Multimedia Appendix 1).

(“games, experimental”[MeSH Terms] OR “gamification”[MeSH Terms] OR “game”[Title/Abstract] OR “gamification”[Title/Abstract] OR “educational game”[Title/Abstract] OR “serious game”[Title/Abstract]) AND (“Nurses”[MeSH Terms] OR “Nursing”[MeSH Terms] OR “Nurse Practitioners”[MeSH Terms] OR Nurses[Ti] OR Nursing[Ti] OR “Nurse Practitioners”[Title/Abstract]) AND (“Education”[MeSH Terms] OR “Education”[Title/Abstract] OR “Learning”[Title/Abstract] OR “Nursing education”[Title/Abstract] OR “Clinical skills”[Title/Abstract] OR “Virtual reality”[Title/Abstract] OR “Virtual learning”[Title/Abstract] OR “Virtual education”[Title/Abstract] OR “Virtualization”[Title/Abstract])).

Study Selection

Articles related to the purpose of our study were screened and selected in 2 steps. In the first stage, the titles and abstracts of the studies were evaluated, and the relevant articles were selected for the second and deeper stage according to their titles and abstracts. In the second step, the authors reviewed the full texts of these articles. Publications that met the inclusion criteria were selected for data extraction (Article selection criteria Textbox 1).

Textbox 1.

Inclusion criteria:

Papers reporting educational games in nursing, published in the English language, and being original.

Exclusion criteria:

Articles without available full texts, lacking published data, duplicated articles, case series, case reports, conference abstracts, and letters to the editors.

Data Extraction

After selecting eligible articles, data extraction began. A total of 4 researchers diligently reviewed the full texts of the selected studies and pulled the required data together. Data related to the objectives of this research were extracted from selected studies. Data about the first author, country, year of publication, the aim of the study, participants, learning objectives, type and name of the game, platform, game features, and main findings of selected studies were extracted in Tables 1 and 2.

Table 1. Specifications of included articles.
IDThe first author (Reference)Country (Year)The aim of the studyParticipants (number)
1Tinoco JD [13]Brazil (2023)Develop and assess a board game’s effectiveness for teaching diagnostic reasoning among nursing students.19 experts and 11 undergraduate nursing students
2Vazquez-Calatayud M [14]Spain (2023)To enhance postgraduate nursing students’ decision-making skills using a game-based learning intervention.66 postgraduate nursing students.
3Morgan DJ [15]United States (2023)Conducting an online game-based learning (GBL) that uses natural frequencies and feedback to teach diagnostic reasoning.90 students
4Morrell B [16]United States (2020)Conducting a cardiovascular-themed educational escape room for undergraduate nursing students, outlining its goals, design, and materials for easy adaptation to other curricula.31 to 68 students
5Morrell B [17]United States (2020)A study was conducted to explore baccalaureate nursing students’ perceptions of a cardiovascular-themed educational escape room.57 students
6Kubin L [18]United States (2020)Evaluation of the effectiveness of escape room activities as educational tools in nursing education.129 students
7Blanie A [19]France (2018)This trial compared the effectiveness of gaming simulation (SG) versus traditional teaching (TT) for improving clinical reasoning (CR).146 students
8Gómez-Urquiza JL [20]Spain (2020)Aimed to explore nursing students’ opinions about an escape room-based game as an evaluation game105 students
9Baek G [21]Korea (2023)Development of a program regarding cardiopulmonary resuscitation training via a web-based serious game for nursing students.A total of 44 participants
10Farsi Z [22]Iran (2018‐2019)This study compared traditional mannequin-based CPRa training with innovative smartphone-based serious game training for nursing students.56 nursing students
11Fijacko N [23]Slovenia (2023)To assess the effectiveness of the MOBICPR game in improving nursing students’ theoretical knowledge and practical skills in adult Basic Life Support (BLS).43 nursing students participated in the study.
12Guti´errez-Puertas L [24]Spain (2019)Design and develop an app that aids nursing students in acquiring knowledge of Basic and Advanced Life Support Techniques.184 students
13Elzeky M [25]Egypt (2020‐2021)Evaluation of the impact of gamified flipped classrooms on nursing students’ competency and learning motivation128 nursing students
14Bayram ŞB [26]Turkey (2021)To improve nursing students’ knowledge and understanding of tracheostomy care.125 nursing students completed both the pretest and post-test
15Breitkreuz K R [27]United States (2019)To assess the usability of the VRb Sterile Urinary Catheter Insertion Game (VRSUCIG) and nursing student reactions.300 pre-licensure nursing students from nine schools.
16Chan K [28]China (2021‐2022)The study evaluated VR-Hospital’s impact on nursing students’ skills, satisfaction, self-confidence, and overall experience.202 students
17Hwang JG [29]Taiwan (2020)A contextual game-based flipped learning approach (GBFL)56 students
18Jung SY [30]Korea (2022)Comparing the feasibility and learning outcomes of a novel pressure ulcer management VR simulation program’s feasibility with video lectures.35 novice nurses
19Koivisto JM [31]Finland (2018‐2019)The objective was to assess the link between game metrics in a simulation and the surgical nursing knowledge of students.280 students
20Koivisto JM [32]Finland (2018‐2019)This study aimed to assess how a simulation game impacts nursing students’ surgical knowledge.385 students
21Lau ST [33]Singapore (2021)This study examines immersive virtual reality (IVR) clinical procedures on mid-career switch students’ knowledge, perceptions, and experiences.34 students
22Kulakc N [34]Turkey (2020)An RCTc was conducted to examine the effects of a serious game-based web application on stoma care education for nursing students.98 students
23Nasirzade A [35]Iran (2022)This study compared the impact of feedback lectures and the BAMd Game on nursing students’ knowledge and skills in burn patient assessment42 students
24Karci HD [36]Turkey (2023)The study examines the role-play gamification’s impact on nursing students’ skills.10 students
25Wang Z [37]China (2021)Aimed to assess the effectiveness of a mobile game app in enhancing ECMO pipeline pre-flushing skills among critical care specialist nurses.86 intensive critical care specialist nurses
26Chang CY [38]Taiwan (2019)The aim was to develop an RPG (role-playing game) to enhance nursing students’ performance in Electrocardiogram training72 4th-year nursing students
27de Beer E.H.M [39]Netherlands (2018‐2019)The study explored how nursing students perceive collaborative problem-solving (CPS) skills development through assignments in the hybrid serious game Carion.181second-year bachelor nursing students (19males and 162females).
28Wong JYH [40]China (2022)To develop and evaluate a serious game, Virtual Emergency Room (ER), aimed at enhancing teamwork attitudes and clinical competency among medical and nursing students during emergency care scenarios.62 final-year medical and nursing students.
29Ropero-Padilla C [41]Spain (2020‐2021)The study aimed to explore nursing students’ experiences and perceptions of using game elements in two nursing courses through a blended-learning approach.149 students
30Calik A [42]Turkey (2021)To evaluate the effectiveness of a serious game (SG) in improving senior nursing students’ knowledge and understanding of COVID-19, including personal protective equipment (PPE) use, quarantine/isolation periods, and symptoms.62 participants in the final analysis.
31Wu SH [43]Taiwan (2017‐2019)To evaluate the effectiveness of a VR game-based training system for preventing needle stick or sharp injuries (NSI) among new nursing and medical interns.109 participants (59 nursing interns, 50 medical interns).
32Al-Mugheed K [44]Cyprus (2019)Aimed to assess the impact of online learning and game-based virtual reality apps on standard precautions.126 students
33Mitchell G [45]United Kingdom (2018‐2019)to assess how a ’serious game’ about influenza impacts nursing students’ attitudes, knowledge, and adoption of the influenza vaccine.430 students
34Ma Z [46]United States (2021)The study aimed to assess how feasible and effective a computer role-playing game (CRPG) is for enhancing nursing students’ empathy, emphasizing immersion and perspective.69 students
35Rodriguez-Ferrer JM [47]Spain (2020‐2021)This research evaluated escapes rooms as a strategy to reduce stigma toward serious mental disorders.197 students
36Chen D [48]China (2023)To evaluate the impact of an Escape room (ER) game on nursing students’ learning attitudes and game flow experience in a Gerontological Nursing course.83 nursing students (41 in the test group, 43 in the control group).
37Idrissi W [49]Morocco (2022)This study aims to explore how serious games affect nursing students’ learning, engagement, and motivation.58 polyvalent nursing students
38Labrague L [50]United States (2023)Teaching delegation skills, a critical competency in nursing, through interactive scenarios.N/A

aCPR: cardiopulmonary resuscitation.

bVR: virtual reality.

cRCT: randomized controlled trial.

dBAM: burn assessment mission.

Table 2. Overview of the included studies that address games for nursing education.
IDLearning objectivesType/Name of the gamePlatformGame featuresMain findings
1Develop diagnostic reasoning in nursingEnfermeiro DiagnosticadorN/Aasearch and organization of clues capable of evidencing the nursing diagnosis presented by patients“Enfermeiro Diagnosticador” is effective in supporting the teaching of diagnostic reasoning in nursing
2Improve decision-making in clinical scenarios, particularly in conflict situations and high-risk protocols.A combined case-based learning and escape room gameConducted in a real-world setting with physical escape roomsCase-based learning scenarios, escape room challenges, puzzles, and ethical dilemmasHigh student engagement, improved decision-making skills, and positive feedback on learning effectiveness and enjoyment
3Teaching diagnostic reasoningDiagnostic reasoning game with natural frequencies feedbackOnline via a web browserEstimates diagnosis probability, provides immediate feedback, and includes a tutorialA single GBLb session almost doubled diagnostic accuracy scores in medical trainees and clinicians, with lasting effects for three months
4Enhance understanding of cardiovascular conditions and clinical reasoning through interactive problem-solvingCardiogenic Shock Educational Escape RoomTraditional classroom setupNine puzzles in a mock hospital; time-limited, with feedbackThis game enables students to pursue a shared objective by collaborating, providing feedback, and seeking assistance
5Enhance understanding of cardiovascular conditionsLive-action cardiovascular critical care escape roomIn personTeams of 4‐5 solve cardiovascular puzzles in 60 min, unlocking a final box to stop a countdownThe escape room-based learning method may be one way to enhance students’ professional practice skills
6Enhancing clinical reasoning, problem-solving, and collaboration among nursing studentsEscape RoomN/ASolving puzzles, riddles, and NCLEX-stylec questionsEscape rooms can be utilized as an effective augmentation to traditional learning methods
7Improving clinical reasoning in nursing studentsLabForGames WarningPlayed on computers with a 3-D interactive environmentStudents practice clinical scenarios, detect deterioration, and communicate using SBARdThis study found no significant CRe difference between SGf and TTg, but SG increased satisfaction and motivation
8N/ANursing Escape RoomIn-person escape room at the University of GranadaFind a fake nursing document in 30 min using clues and a classroom keyThe escape room learning game provided a positive experience for students, noted for being enjoyable, engaging, and motivating
9Cardiopulmonary resuscitation training in nursing studentsAdvanced Cardiac Pulmonary Resuscitation (ACPR)Web-based platform hosted on Amazon Web Services (AWS)A realistic cardiac resuscitation game with sequential learning, interactive 3D environment, and personalized feedbackThe program effectively enhanced nursing students’ cardiopulmonary knowledge, confidence, problem-solving, and learning transfer
10Improving CPR training and skillsSerious game for CPR trainingN/A Using smartphonesSelf-learning, step-by-step instructions, self-assessment, feedback on tasks, retry options, and communication with researchers via group chatBoth simulation and serious game training improved CPRh skills, suggesting a multimodal educational approach could be beneficial
11To enhance the participants’ theoretical knowledge and practical skills in adult BLS, particularly their ability to perform cardiopulmonary resuscitation (CPRh) and use an automated external defibrillator (AED)MOBICPRThe game was played on a Samsung Galaxy A13 smartphoneThe game simulates BLS for out-of-hospital cardiac arrest (OHCA) using gestures, scores, and 2021 European Resuscitation Council (ERC) guidelines to teach CPRhMOBICPR significantly improved BLS knowledge and skills, suggesting serious games enhance nursing students’ BLS training
12Enhancing students’ knowledge of Basic and Advanced Life Support TechniquesGuess It (SVUAL)Mobile appPhases of keyword guessing, retention testing, and knowledge reinforcement based on life support techniquesThe app has demonstrated high content quality and user-friendliness, enhancing nursing students’ knowledge and information retention
13Enhance nursing students’ competency and learning motivationGamified Flipped Classroom (FC) for Nursing FundamentalsMoodle platform with additional gamification featuresIncludes quizzes with varying difficulty levels, badges, leaderboards, ranks, levels/unlocks, and pointsGamified flipped classrooms boost nursing students’ motivation, preparation, skills, knowledge, and confidence in lab practice
14Learning tracheostomy care and remember their prior knowledgeTracheostomy care knowledge test (TCKT)The game was available on a dedicated website [51] and could be played on a computerThe game is a 10 min interactive tool consisting of six stages. The player must complete each stage correctly to progress to the nextThe game effectively improved tracheostomy care knowledge, especially for first-year students, enhancing learning enjoyment and realism
15To practice sterile urinary catheter insertion skills using VRiVR Sterile Urinary Catheter Insertion Game (VR-SUCIG)N/AVirtual feedback on technique, scoring, cue cards, and visual cues for contaminationThe game had medium usability; students found it engaging and effective for practice
16Enhancing nursing students’ skills, satisfaction, self-confidence, and overall experienceVirtual Reality Hospital (VR-Hosp)HTC Vive CosmosSingle-user VR game with 3D ward, scenarios, speech recognition, randomized tasks, and NTSj developmentThe positive outcomes provide a foundation for developing IVRk activities in nursing education
17Exploring the situation of intravenous injection flipped learningIntravenous Injection GameN/AGame-based learning, decision-making scenarios, skills practice, and group discussionsStudents using the new method excelled in intravenous injection comprehension, motivation, and critical thinking compared to conventional methods
18Improving pressure ulcer management trainingPU-VRSimlUnity 3DThe game simulates pressure ulcer care, enhancing critical thinking, self-efficacy, and clinical judgment using VRPU-VRSim enhances novice nurses’ PUm management skills
19Improving surgical nursing knowledgeSimulation game with surgical nursing scenariosDesktop virtual simulationSimulation game with realistic nursing scenarios, learning-enhancing elements, and flexible scoring system for educational researchHigher game scores correlated with better surgical nursing knowledge; time spent playing had no impact
20Improving surgical nursing knowledge 3D simulation game developed with UnityN/AIncludes five surgical patient scenarios, realistic graphics, animations, and interactive elements for interviewing, assessing, and implementing nursing interventionsThis study demonstrates that a simulation game effectively enhances nursing students’ knowledge in surgical nursing
21Enhancing intravenous therapy and insulin therapy skillsIVR clinical procedures simulation The participants used Meta Quest 2 VR headsetsIVR simulation for intravenous therapy and insulin with 3D avatars, practice/assessment modes, and virtual patientsIVR simulation can enhance clinical procedure knowledge in mid-career students
22Enhancing stoma care and colostomy irrigation knowledgeN/AWeb-based applicationThe game allowed students to practice stoma care and colostomy irrigation skills in a simulated environment, reinforcing the theoretical knowledge they had gainedStudents’ knowledge and skill scores improved significantly as they spent more time with the serious game
23Learning of burn patient assessmentBAMn Game Web-based game accessible via computers or mobile devicesInteractive game: burn assessment, real images, videos, feedback, competitive scoringNursing students using the BAM game excelled in knowledge and skill development
24Enhancing skills related to internal medicineRole-Play-Based GamificationN/ARole-playing various medical scenarios, developing nursing skills, enhancing communication, incorporating scoring systems and symbolic rewards, and embedding fun and humor to facilitate learningGamification enhanced students’ motivation and retention in learning nursing care and communication skills
25improving ECMO pipeline preflushing skillsN/AMobile phonesInteractive stages simulating ECMO pipeline preflushing include 61 steps with real-time feedback and scoringThis study indicates that a game-based mobile app could be more effective than traditional Chinese lecture-practice methods for teaching ECMO pipeline preflushing to critical care specialist nurses
26Enhance ECGo training in nursingECG Clinical Context Role-Playing GameRPGp Maker MV by Enterbrain IncorporatedThis ECG game uses RPG Maker MV to enhance learning with challenges, fights, and storylinesStudents using this game outperformed those in traditional instruction in learning, attitude, and critical thinking
27The primary learning objective was to improve students’ collaborative problem-solving skills, encompassing both social and cognitive skillsThe game is called CarionThe game uses multiple platforms: Wijklink (an online collaboration platform), Blackboard (the university’s online learning environment), in-school learning environments, and real-life district assignmentsOne semester (20 wk, 840 study hours)Students used each other’s strengths to enhance teamwork and problem-solving through innovative serious games
28(1) Competency in history taking and physical assessment skills; (2) diagnostic skills, alertness, and treatment skills; (3) clinical procedural skills and prioritization during emergency situations. (4) professionalism, responsibility, and a caring attitudeVirtual Emergency room (ER)Web-based application created with Tumult Hype, played online on laptopInteractive emergency care game with roles, scoring, and feedback to enhance learning and clinical skillsVirtual ER improved teamwork attitudes; activists and pragmatists benefited most; students rated it positively
29N/AN/AGoogle Meet and Google Classroom for online sessionsGame elements in blended learning were assessed via focus groups, with online gamified activities and rewardsThis study presents new findings on using game elements in blended learning, demonstrating their effectiveness in teaching key clinical and teamwork skills like creativity, communication, and responsibility
30The learning objectives included understanding virus incubation time, recognizing COVID-19 symptoms, proper donning and removing PPEq, and knowledge about quarantine and isolation periodsN/AN/AThe game featured login, avatars, progress tracking, PPE, symptoms, and quarantine management, developed on Articulate Students’ knowledge improved significantly on isolation times and quarantine; PPE donning showed a non-significant increase
31Increase familiarity and confidence, reduce anxiety in practicing universal precautions for NSIr prevention, and reduce NSI incidence during the internshipVR game-based training for occupational NSI preventionUnity 3DImmersive VR scenarios, random scenarios with safe/unsafe behaviors, real-time feedback, performance assessment, and elements of surprise and uncertaintyThe VR training improved accuracy, decreased anxiety, and enhanced familiarity and confidence in NSI prevention, with better retention observed two months post training
32Enhancing standard precautionsN/AMobile phonesInteractive game with scenarios, video demos, made in Adobe FlashOnline education and VR games significantly improved nursing students’ performance
33Evaluating attitudes, knowledge, and adoption of the influenza vaccineFlu Bee GameHTML5 web application, accessible via web browsers on any deviceInteractive influenza questions, build ’honeycomb path,\' myth-busting, feedback, leaderboardsThe game can enhance understanding and increase the likelihood of vaccination
34Enhancing empathy, emphasizing immersion, and perspectiveThat Dragon, Cancer - a narrative-focused video game VR (Oculus Go) and non-VR (Dell laptops, iPads)VR versus non-VR, role perspectives, interactive emotional scenariosThe results of this study demonstrate that role-playing games are viable for nursing education, with insights into empathy training
35raising awareness about stigmatizing attitudes toward individuals with serious mental disordersN/AOnline, using the Genial.ly digital platformTeams of 4 solve linear puzzles in a 60 min escape room, exploring the life of a person with serious mental illness, reflecting real-life challenges like stigma and medication side effectsVirtual escape rooms can serve as an effective method for educating health sciences students
36To improve students’ attitudes towards learning and enhance their game flow experience related to safe medication use in older adultsN/APhysical venue designed as a geriatric nursing training roomImmersive escape room experience with puzzles, time constraints, and a narrative involving medication safety for older adultsThe ER game significantly improved learning attitudes and game flow experience in the test group compared to the control group
37learning of nursing care in pediatricsSerious game for pediatric nursing practiceVTS Editor Education version 2 (game design), VTS Player (access), VTS Perform (progress tracking)Three scenarios (gastric feeding, peripheral venous access, bronchial aspiration), scoring system, feedback, performance tracking, attempts, and error recordingThe game significantly improved clinical knowledge and motivation, with students showing high satisfaction and engagement
38Enhancing delegation skillsDelegation PokerClassroom-based, using physical cards and a boardStudents used modified poker cards to select delegation strategies in nursing scenarios, earning competitive pointsThe game was an engaging and educational tool that successfully taught nursing students the nuances of delegation in a fun and interactive manner

aNot applicable.

bGBL: game-based learning.

cNCLEX: National Council Licensure Examination.

dSBAR: Situation, Background, Assessment, and Recommendation.

eCR: clinical reasoning.

fSG: serious game.

gTT: traditional teaching.

hCPR: cardiopulmonary resuscitation.

iVR: virtual reality.

jNTS: nontechnical skills.

kIVR: immersive virtual reality.

lPU-VRSim: pressure ulcer management virtual reality simulation.

mPU: pressure ulcer.

nBAM: burn assessment mission.

oECG: electrocardiography.

pRPG: role-playing game.

qPPE: personal protective equipment.

rNSI: needle stick or sharp injuries.

Quality Assessment and Bias Risk Evaluation

To enhance the quality, 3 authors independently evaluated the eligible studies for risk of bias to minimize any probable bias risk using the NOS risk assessment tool (Table 3). Worthy to mention that a total score of 9 in 3 categories is calculated in this numerical bias assessment tool. These three categories include selection, comparability, and exposure or outcome. Numerical values of 4, 2, and 3 are attributed to these categories, respectively. A maximum scale of 9 is going to be expected for each of the included studies by summing these numbers together.

Table 3. Newcastle-Ottawa Scale bias risk assessment of the study. Good quality: 3 or 4 stars in selection domain AND 1 or 2 stars in comparability domain AND 2 or 3 stars in exposure or outcome domain; fair quality: 2 stars in selection domain AND 1 or 2 stars in comparability domain AND 2 or 3 stars in exposure or outcome domain; poor quality: 0 or 1 star in selection domain OR 0 stars in comparability domain OR 0 or 1 stars in exposure or outcome domain.
IDSelection (out of 4)Comparability (out of 2)Exposure/Outcome (out of 3)Total (Out of 9)
13238
24239
32136
44239
53227
63227
73238
82237
93238
104127
113238
124239
133238
143126
154239
163238
173238
182125
193227
203227
213238
224239
233238
244239
253036
264228
271236
282136
294239
303036
313238
323137
334239
344239
352125
363137
372226
382136

Results

Data Sources

In this study, 801 articles were initially retrieved using the specified search strategy in the databases of PubMed, Embase, Scopus, and Web of Science.

Study Selection

In total, 44 duplicate articles were removed, and 757 studies were screened. After applying the inclusion and exclusion criteria, 719 articles were excluded, leaving 38 articles for full-text review (Figure 1).

Figure 1. PRISMA (Preferred Reporting Items for Systematic Reviews and Meta-Analyses) 2020 flow diagram of the study retrieval process.

Data Extraction

The included articles were conducted in the countries of Brazil (n=1), Korea (n=2), Turkey (n=4), China (n=4), Netherlands (n=1), United States (n=7), Taiwan (n=3), Egypt (n=1), Iran (n=2), Spain (n=5), Morocco (n=1), Finland (n=1), Singapore (n=1), United Kingdom (n=1), France (n=1), Cyprus (n=1), and Slovenia (n=1) and were published between 2018 and 2023 (Figure 2). The final included studies were conducted over a range of years, from 2017 to 2023. Figure 3 provides a visual summary of these timeframes.

Figure 2. Geographical distribution of the countries where the studies were conducted.
Figure 3. Overview of study conduction years.

Quality Assessment and Bias Risk Evaluation

As shown in Table 3, according to the NOS risk assessment tool, out of 38 included articles, 36 articles were of good quality (≥6), 2 articles were of fair quality (5≥, >2), and none of the articles were of poor quality (2≥).

Main Findings

Our results showed that several learning objectives can be conducted by GBL. These objectives included developing diagnostic reasoning, enhancing knowledge and cognitive skills, and improving training methods (Figure 4).

Figure 4. Overview of studies’ objectives.

We also showed that different platforms were used for the games. While many games used web-based platforms, few were conducted in person, and some were developed in-app formats for smartphones. Game platforms are compiled in Figure 5, providing an overview of the different game platforms. In addition, while we summarized the 3 key terms of GBL and its benefits and limitations in Figure 6, we illustrated how various platforms and game types aligned with distinct learning objectives in nursing education in Figure 7.

Figure 5. Overview of game platforms.
Figure 6. Summary of the benefits and limitations of game-based learning in nursing education.
Figure 7. Platforms and game types associated with specific learning objectives in nursing education. VR: virtual reality.

Finally, multiple studies were conducted in the Asia-Pacific region, where we provided a more in-depth analysis of the region’s unique approaches to nursing education and the integration of technology. These studies, involving Asia-Pacific Islander Nursing (APIN) student populations from countries such as Korea, China, and Singapore, highlighted strong engagement with mobile and virtual reality (VR)–based GBL tools. These studies also reported improvements in clinical skills, knowledge retention, and student motivation following the use of these technologies.


Principal Findings

We showed that a broad range of learning objectives, such as developing diagnostic reasoning, enhancing knowledge and cognitive skills, and improving training methods, can be conducted by a game-based platform. We also showed that while many games used web-based platforms, few were conducted in person, and some were developed in app formats for smartphones. The emergence of game-based learning in recent years has led to significant changes in the health education system and curricula [52]. These methods are gaining considerable attention for their potential to boost student motivation and engagement in the learning process. The educators are offered new novel methods to enhance the education process, specifically medical education, by the premise of using serious games and gamification of the learning processes.

Overview of Studies and Learning Objectives

After a thorough evaluation of 38 studies, our results indicated that the most frequent year for conducting studies was 2023, with contributions from countries like Brazil, Korea, and the United States. The United States contributed the most studies, covering topics such as sterile catheter insertion, diagnostic reasoning, and empathy training. The main learning included developing diagnostic reasoning, enhancing nursing knowledge and cognitive skills, and improving practical training methods such as cardiopulmonary resuscitation (CPR) and tracheostomy care. In addition, a focus on fostering student engagement, motivation, critical thinking, and collaborative problem-solving. Various platforms were used, ranging from web-based applications like Moodle and Amazon Web Services to advanced VR tools such as HTC Vive Cosmos and mobile apps. The key findings demonstrated that serious games and VR simulations were highly effective in boosting nursing students’ knowledge, practical skills, and confidence. These techniques also enhanced collaborative problem-solving, critical thinking, and motivation, with significant improvements in clinical reasoning and knowledge retention.

GBL and the Range of Targeted and Enhanced Skills

Studies from Brazil and Korea demonstrate that GBL effectively enhances diagnostic reasoning and CPR skills through more engaging and interactive approaches than traditional methods [19,21]. These findings are reinforced by research across countries, including Turkey, where games improved tracheostomy care, and the Netherlands, which highlighted the development of collaborative problem-solving skills through serious games [26,39]. For developing skills for high-risk medical procedures, such as extracorporeal membrane oxygenation pipeline handling and pressure ulcer management, the eligible studies used serious games [30,37]. VR-based learning, as studied in the United States and China, enables students to practice sterile techniques and clinical care in immersive environments, boosting their confidence and competence [27,38]. In addition, studies have shown how serious games can rapidly adapt to global challenges, such as improving COVID-19 protocols [42]. Finally, escape-room games have proven effective in fostering clinical reasoning, collaboration, and reducing stigma toward mental health disorders [47].

Overall, the range of skills enhanced through educational games in nursing includes technical procedures, cognitive decision-making, communication, teamwork, and professional empathy, demonstrating the broad and versatile impact of GBL. Although some of these studies were conducted in western contexts, the core educational benefits are equally relevant and transferable to Asia-Pacific nursing students.

Platforms’ and Game Types’ Association With Learning Objectives

According to our results, the following platforms and game types are linked to distinct learning objectives in nursing education:

  1. Diagnostic reasoning skills games: Board games like “Enfermeiro Diagnosticador” and web-based tools enhance diagnostic reasoning [13].
  2. CPR and life support training: Web-based and mobile games like mobile CPR improve CPR training through interactive simulations [13,15,23]. In addition, mobile apps like Guess It and gamified flipped classrooms enhance knowledge retention in life support and nursing fundamentals with features such as quizzes and leaderboards [24,25].
  3. Clinical procedural skills: Virtual reality platforms, such as virtual reality sterile urinary catheter insertion game and pressure ulcer management virtual reality simulation, offer immersive practice for skills like catheter insertion and pressure ulcer management [27,30].
  4. Teamwork, clinical competency, and emergency skills: Escape rooms and virtual emergency room simulations focus on teamwork and clinical competency by presenting problem-solving tasks in high-pressure scenarios [20,40,48].
  5. Specialized skills: Role-playing games improve specialized skills, such as electrocardiogram interpretation, and foster empathy and communication [36,38].

These diverse platforms effectively align with educational goals, combining interactive, scenario-based learning with feedback and collaboration to enhance student engagement, clinical skills, and decision-making. Figure 7 illustrates how various platforms and game types align with distinct learning objectives in nursing education.

Depending on the game formats, these games show strong potential for adaptation across Asia-Pacific contexts. While VR and web-based platforms suit technologically advanced regions and might require more complex infrastructure, mobile games and gamified classrooms may be more feasible for underresourced regions of APIN settings.

Impact of GBL on Learning Outcomes and Their Broader Discussion in Nursing Education

The comparative value of simulation-based gaming versus traditional teaching methods in nursing education demonstrates the significant benefits of serious games in enhancing clinical skills, knowledge retention, and decision-making, which aligns with the previously mentioned facts from the available literature in this sector. These studies demonstrate that simulation-based gaming provides a dynamic, effective alternative to traditional methods, offering nursing students not only technical proficiency but also the critical thinking, teamwork, and decision-making skills needed in modern health care environments. These games offer flexibility, engagement, and the ability to simulate real-life scenarios in a low-risk, repeatable format, making them a valuable tool in nursing education. Ultimately, this novel method has significant potential to minimize costly bedside teaching and enhance the efficiency of medical practice design [1]. Ultimately, GBL represents a novel and transformative method that has the potential to enhance the efficiency and effectiveness of nursing education globally. Furthermore, for APIN students, GBL can offer an effective way to bridge gaps caused by limited clinical placements or cultural and language barriers. Their adaptability makes them especially valuable in diverse Asia-Pacific settings.

Challenges

Although GBL methods emerge as effective and beneficial methods, there are still significant challenges and limitations to their use [1]. One major issue is the “expertise reversal effect,” which highlights how the effectiveness of serious games varies based on the learner’s skill level. For instance, while these games may be beneficial for experts, they may not be as useful for beginners. Ensuring that new learners can still benefit from the game is crucial to their success [53]. Developing adaptive games that can adjust difficulty level according to player level can emerge as an effective solution to this challenge. Another challenge is the high cost of developing serious games, which can run into thousands of dollars. Creating these educational tools requires careful consideration of both cost and efficiency to ensure they remain feasible for widespread use [1]. Creation of games in collaboration with institutes and seeking sponsorship or grants can reduce the development costs. In addition to financial constraints, the need for training instructors to effectively implement the games and providing adequate technical support are common hurdles. Without proper training and support, the potential of serious games may not be fully realized [54]. Establishment of technical support teams and training standardized instructors can maximize the benefits of these games.

One major issue is the “expertise reversal effect,” which highlights how the effectiveness of serious games varies based on the learner’s skill level. For instance, while these games may be beneficial for experts, they may not be as useful for beginners. Ensuring that new learners can still benefit from the game is crucial to their success [53]. Developing adaptive games that can adjust difficulty level according to player level can emerge as an effective solution to this challenge.

In addition to financial constraints, the need for training instructors to effectively implement the games and providing adequate technical support are common hurdles. Without proper training and support, the potential of serious games may not be fully realized [54]. Establishment of technical support teams and training standardized instructors can maximize the benefits of these games.

Limited funding and access to professional developers, along with a lack of trained educators, can complicate these issues further and lead to a much more challenging situation in underresourced Asia-Pacific regions. Addressing these challenges is essential to making serious games a more practical and accessible tool in educational settings, particularly in medical training, where their application has the potential to significantly enhance learning outcomes if used correctly. Figure 6 provides a summary of the discussed benefits and limitations. Finally, it is noteworthy to mention that game-based learning in nursing is a novel and beneficial method, and by addressing its limitations, we hope it becomes more widespread in the future. Finally, it is noteworthy to mention that game-based learning in nursing is a novel and beneficial method, and by addressing its limitations, we hope it becomes more widespread in the future.

Lastly, it is noteworthy to mention that game-based learning in nursing is a novel and beneficial method, and by addressing its limitations, we hope it becomes more widespread in the future.

Asia-Pacific Approaches to Technology-Enhanced Nursing Education

One group of the included studies was conducted in Asia-Pacific countries, which mainly originated from Korea, Taiwan, China, and Singapore, alongside Iran. These studies highlight a regional trend of incorporating advanced digital technologies in nursing education. A wide range of platforms was used in this section of the literature, including VR technologies, web-based platforms, mobile apps, and virtual environments. The primary goals of these studies encompassed a wide range of areas, including clinical skills development, critical thinking enhancement, infection control practices, CPR training, and emergency care [21,22,29,30,33,35,37,40,43,48,55]. According to these findings, in this region, there is a strong emphasis on innovation, rapid adoption of new technologies, and a cultural value placed on education and professional development. Understanding these dynamics highlights the region’s distinct approach to advancing nursing education through technology-driven methods. However, the development, adoption, and effectiveness of GBL can be influenced by cultural factors prevalent in the Asia-Pacific context. One issue is that in collectivist societies, common in many parts of Asia, students may prioritize group harmony and respect for authorities, which can affect their engagement in interactive and competitive learning environments like GBL [56,57]. Since Western GBL approaches often emphasize individualism and assertiveness, they may not fully align with the values common in Asia-Pacific contexts. Adapting game content to focus more on collaboration, respect for authority, and cultural relevance can improve acceptance among APIN students. While this situation provides a challenging base for the implementation of GBL, the acceptance of these learning methods also varies across different cultures of Asia-Pacific countries, necessitating culturally sensitive designs and strategies. Ultimately, in low-resource regions of this area, limited access to technological infrastructure can pose challenges to the widespread adoption of GBL [58].

Limitations and Future Prospects

This study has several limitations. First, it only included English-language publications, potentially omitting valuable insights from non-English studies, which may affect the comprehensiveness of our findings. Including multilingual studies can highlight local innovations in many aspects, such as region-specific game designs or unique instructional methods. In addition, publication bias could skew results since positive studies are more likely to be published. Variability in definitions and classifications of GBL and a lack of standardized measurement tools complicate data interpretation. Finally, our research did not explore the long-term effects of GBL on nursing competencies and patient outcomes, which necessitates longitudinal studies for a comprehensive understanding. Looking ahead, future research should aim to include multilingual studies to broaden perspectives on GBL in nursing education. Longitudinal studies are essential to assess the enduring impacts of GBL on clinical competencies and patient care outcomes. In addition, developing standardized assessment tools will help unify definitions and improve the comparability of research findings, ultimately enhancing the evidence base for GBL’s effectiveness.

Conclusion

To conclude, the premise of GBL and its infiltration into nursing education represents a novel yet challenging approach that enhances student engagement, motivation, and clinical skills. The feasibility and benefits of this method lead to educators creating immersive learning environments that promote critical thinking and collaborative problem-solving. However, like any other new approach, it introduces a few challenges to the education system. Addressing these limitations is crucial for maximizing the potential of GBL in nursing education. As the field continues to evolve, future research should aim to broaden perspectives through multilingual studies and assess the long-term impacts of GBL on nursing competencies and patient care outcomes. Overall, the promising benefits of GBL could significantly enhance the quality of nursing education and ultimately improve health care delivery. In the APIN, implementing GBL requires sensitivity to cultural values. Educators should design collaborative, culturally aligned approaches and strategies, plus ensure accessibility despite resource limitations.

Acknowledgments

This study was extracted from the research project with code IR.SMUMS.REC.1403.034 entitled “Design, development, and evaluation of an educational game to improve the clinical skills of nursing students” that was approved at Smart University of Medical Sciences in 2024. We thank all the participants for taking the time to contribute to the study. This article is the result of the MSc dissertation on Medical Education at Smart University of Medical Sciences. We thank all the participants for taking the time to participate in the study. AI tools were used solely to improve the clarity and readability of the manuscript. All content, including interpretations, findings, and paraphrasing, was developed by the authors, and no factual information was generated by artificial intelligence.

Data Availability

The authors stated that all information provided in this article could be shared.

Authors' Contributions

Conceptualization: EM, SA. Data curation: AM. Formal analysis: FS. Supervision: SA. Writing – original draft: HZH, AA, NA, AT, FS, AM, EM. Writing – review & editing: SA, HZH, AA, EM.

Conflicts of Interest

None declared.

Multimedia Appendix 1

Search query of databases.

PDF File, 68 KB

Checklist 1

PRISMA (Preferred Reporting Items for Systematic Reviews and Meta-Analyses) 2020 checklist.

DOCX File, 33 KB

  1. Xu Y, Lau Y, Cheng LJ, Lau ST. Learning experiences of game-based educational intervention in nursing students: a systematic mixed-studies review. Nurse Educ Today. Dec 2021;107:105139. [CrossRef] [Medline]
  2. Esmail S, Concannon B. Immersive virtual reality and AI (generative pretrained transformer) to enhance student preparedness for objective structured clinical examinations: mixed methods study. JMIR Serious Games. Apr 30, 2025;13:e69428. [CrossRef] [Medline]
  3. Martín-Valero R, Vega-Morales A Sr, Martín-Vega FJ, Rodriguez-Huguet M, Rodríguez-Martínez MC, Vinolo-Gil MJ. Effectiveness of augmented reality in the teaching of health university students: quasi-experimental study. JMIR Serious Games. Mar 27, 2025;13:e54312. [CrossRef] [Medline]
  4. Kuruca Ozdemir E, Dinc L. Game-based learning in undergraduate nursing education: a systematic review of mixed-method studies. Nurse Educ Pract. Jul 2022;62:103375. [CrossRef] [Medline]
  5. Lee M, Shin S, Lee M, Hong E. Educational outcomes of digital serious games in nursing education: a systematic review and meta-analysis of randomized controlled trials. BMC Med Educ. Dec 18, 2024;24(1):1458. [CrossRef] [Medline]
  6. Safeena Beevi SS, Veragi OP. Game based learning in nursing - an innovative strategy. Medicon Med Sci. 2023;4(2):4-7.
  7. Tavares N. The use and impact of game-based learning on the learning experience and knowledge retention of nursing undergraduate students: a systematic literature review. Nurse Educ Today. Oct 2022;117:105484. [CrossRef] [Medline]
  8. Lopreiato JO. Healthcare simulation dictionary. Agency for Healthcare Research and Quality; 2025.
  9. Pan L, Tlili A, Li J, et al. How to implement game-based learning in a smart classroom? A model based on a systematic literature review and delphi method. Front Psychol. 2021;12:749837. [CrossRef] [Medline]
  10. Xu M, Luo Y, Zhang Y, Xia R, Qian H, Zou X. Game-based learning in medical education. Front Public Health. 2023;11:1113682. [CrossRef] [Medline]
  11. Gudadappanavar AM, Benni JM, Javali SB. Effectiveness of the game-based learning over traditional teaching-learning strategy to instruct pharmacology for Phase II medical students. J Educ Health Promot. 2021;10:91. [CrossRef] [Medline]
  12. Wan K, King V, Chan K. Examining essential flow antecedents to promote students’ self-regulated learning and acceptance of use in a game-based learning classroom. EJEL. 2021;19(6):531-547. [CrossRef]
  13. Tinôco J, Silva LSD, de Medeiros TM, et al. Enfermeiro Diagnosticador” board game for teaching diagnostic reasoning in nursing: a quasi-experimental study. Acta Paulista de Enfermagem. 2023;36:eAPE00001. [CrossRef]
  14. Vázquez-Calatayud M, García-García R, Regaira-Martínez E, Gómez-Urquiza J. Real-world and game-based learning to enhance decision-making. Nurse Educ Today. Sep 2024;140:106276. [CrossRef] [Medline]
  15. Morgan DJ, Scherer L, Pineles L, et al. Game-based learning to improve diagnostic accuracy: a pilot randomized-controlled trial. Diagnosis (Berl). May 1, 2024;11(2):136-141. [CrossRef] [Medline]
  16. Morrell B, Eukel HN. Shocking escape: a cardiac escape room for undergraduate nursing students. Simul Gaming. Feb 2021;52(1):72-78. [CrossRef]
  17. Morrell BLM, Eukel HN, Santurri LE. Soft skills and implications for future professional practice: qualitative findings of a nursing education escape room. Nurse Educ Today. Oct 2020;93:104462. [CrossRef] [Medline]
  18. Kubin L. Using an escape activity in the classroom to enhance nursing student learning. Clin Simul Nurs. Oct 2020;47:52-56. [CrossRef]
  19. Blanié A, Amorim MA, Benhamou D. Comparative value of a simulation by gaming and a traditional teaching method to improve clinical reasoning skills necessary to detect patient deterioration: a randomized study in nursing students. BMC Med Educ. Feb 19, 2020;20(1):53. [CrossRef] [Medline]
  20. Gómez-Urquiza JL, Hueso-Montoro C, Correa-Rodríguez M, et al. Nursing students’ experience using an escape room for training clinical skills and competencies on emergency care: A qualitative observational study. Medicine (Baltimore). Jul 29, 2022;101(30):e30004. [CrossRef] [Medline]
  21. Baek G, Lee E. Development and effects of advanced cardiac resuscitation nursing education program using web-based serious game: application of the IPO model. BMC Nurs. Mar 27, 2024;23(1):206. [CrossRef] [Medline]
  22. Farsi Z, Yazdani M, Butler S, Nezamzadeh M, Mirlashari J. Comparative effectiveness of simulation versus serious game for training nursing students in cardiopulmonary resuscitation: a randomized control trial. International Journal of Computer Games Technology. Mar 24, 2021;2021(1):1-12. [CrossRef]
  23. Fijačko N, Masterson Creber R, Metličar Š, et al. Effects of a serious smartphone game on nursing students’ theoretical knowledge and practical skills in adult basic life support: randomized wait list-controlled trial. JMIR Serious Games. Apr 5, 2024;12:e56037. [CrossRef] [Medline]
  24. Gutiérrez-Puertas L, García-Viola A, Márquez-Hernández VV, Garrido-Molina JM, Granados-Gámez G, Aguilera-Manrique G. Guess it (SVUAL): an app designed to help nursing students acquire and retain knowledge about basic and advanced life support techniques. Nurse Educ Pract. Jan 2021;50:102961. [CrossRef] [Medline]
  25. Elzeky MEH, Elhabashy HMM, Ali WGM, Allam SME. Effect of gamified flipped classroom on improving nursing students’ skills competency and learning motivation: a randomized controlled trial. BMC Nurs. Nov 16, 2022;21(1):316. [CrossRef] [Medline]
  26. Biyik Bayram Ş, Çalişkan N, Gülnar E. The effect of web-based tracheostomy care game on nursing students’ knowledge levels and their views of the process. Clinical and Experimental Health Sciences. 2023;13(1):41-47. [CrossRef]
  27. Breitkreuz KR, Kardong-Edgren S, Gilbert GE, et al. A multi-site study examining the usability of a virtual reality game designed to improve retention of sterile catheterization skills in nursing students. Simul Gaming. Apr 2021;52(2):169-184. [CrossRef]
  28. Chan K, Kor PPK, Liu JYW, Cheung K, Lai T, Kwan RYC. The use of immersive virtual reality training for developing nontechnical skills among nursing students: multimethods study. Asian Pac Isl Nurs J. Jul 10, 2024;8:e58818. [CrossRef] [Medline]
  29. Hwang GJ, Chang CY. Facilitating decision-making performances in nursing treatments: a contextual digital game-based flipped learning approach. Interact Learn Environ. 2020;31:1-16. [CrossRef]
  30. Jung SY, Moon KJ. Pressure ulcer management virtual reality simulation (PU-VRSim) for novice nurses: mixed methods study. JMIR Serious Games. Jun 24, 2024;12:e53165. [CrossRef] [Medline]
  31. Koivisto JM, Buure T, Engblom J, Rosqvist K, Haavisto E. Association between game metrics in a simulation game and nursing students’ surgical nursing knowledge - a quasi-experimental study. BMC Nurs. Jan 2, 2024;23(1):16. [CrossRef] [Medline]
  32. Koivisto JM, Buure T, Engblom J, Rosqvist K, Haavisto E. The effectiveness of simulation game on nursing students’ surgical nursing knowledge—a quasi-experimental study. Teach Learn Nurs. Jan 2024;19(1):e22-e29. [CrossRef]
  33. Lau ST, Liaw SY, Loh WL, et al. Mid-career switch nursing students’ perceptions and experiences of using immersive virtual reality for clinical skills learning: a mixed methods study. Nurse Educ Today. May 2023;124:105760. [CrossRef] [Medline]
  34. Kulakaç N, Çilingir D. The effect of a serious game-based web application on stoma care education for nursing students: a randomized controlled trial. Teaching and Learning in Nursing. Jan 2024;19(1):e126-e132. [CrossRef]
  35. Nasirzade A, Deldar K, Froutan R, Shakeri MT. Comparison of the effects of burn assessment mission game with feedback lecture on nursing students’ knowledge and skills in the burn patients’ assessment: a randomized clinical trial. BMC Med Inform Decis Mak. Jun 5, 2024;24(1):157. [CrossRef] [Medline]
  36. Karcı HD, Bektaş Akpınar N, Özcan Yüce U. Role-play based gamification for communication skills and nursing competence in internal medicine nursing. Journal of Nursology. 2024;27(2):88-100. [CrossRef]
  37. Wang Z, Gu R, Wang J, et al. Effectiveness of a game-based mobile application in educating intensive critical care specialist nurses on ECMO pipeline preflushing: a quasi-experimental trial (preprint). JMIR Serious Games. Preprint posted online on 2022. [CrossRef]
  38. Chang CY, Kao CH, Hwang GJ, Lin FH. From experiencing to critical thinking: a contextual game-based learning approach to improving nursing students’ performance in Electrocardiogram training. Educ Technol Res Dev. 2019;68. [CrossRef]
  39. de Beer E, van Os-Medendorp HH, Groeneveld S, Jukema J. Perceived contribution of a hybrid serious game to the development of collaborative problem solving among undergraduate nursing students: a mixed method design. Nurse Educ Pract. Nov 2023;73:103794. [CrossRef] [Medline]
  40. Wong JYH, Ko J, Nam S, et al. Virtual ER, a serious game for interprofessional education to enhance teamwork in medical and nursing undergraduates: development and evaluation study. JMIR Serious Games. Jul 14, 2022;10(3):e35269. [CrossRef] [Medline]
  41. Ropero-Padilla C, Rodriguez-Arrastia M, Martinez-Ortigosa A, Salas-Medina P, Folch Ayora A, Roman P. A gameful blended-learning experience in nursing: a qualitative focus group study. Nurse Educ Today. Nov 2021;106:105109. [CrossRef] [Medline]
  42. Calik A, Cakmak B, Kapucu S, Inkaya B. The effectiveness of serious games designed for infection prevention and promotion of safe behaviors of senior nursing students during the COVID-19 pandemic. Am J Infect Control. Dec 2022;50(12):1360-1367. [CrossRef] [Medline]
  43. Wu SH, Huang CC, Huang SS, et al. Effect of virtual reality training to decreases rates of needle stick/sharp injuries in new-coming medical and nursing interns in Taiwan. J Educ Eval Health Prof. Jan 2020;17:1. [CrossRef] [Medline]
  44. Al-Mugheed K, Bayraktar N, Al-Bsheish M, et al. Effectiveness of game-based virtual reality phone application and online education on knowledge, attitude and compliance of standard precautions among nursing students. PLoS One. 2022;17(11):e0275130. [CrossRef] [Medline]
  45. Mitchell G, Leonard L, Carter G, Santin O, Brown Wilson C. Evaluation of a “serious game” on nursing student knowledge and uptake of influenza vaccination. PLoS One. 2021;16(1):e0245389. [CrossRef] [Medline]
  46. Ma Z, Huang KT, Yao L. Feasibility of a computer role-playing game to promote empathy in nursing students: the role of immersiveness and perspective. Cyberpsychol Behav Soc Netw. Nov 2021;24(11):750-755. [CrossRef] [Medline]
  47. Rodríguez-Ferrer JM, Manzano-León A, Cangas AJ, et al. Acquisition of learning and empathy towards patients in nursing students through online escape room: an exploratory qualitative study. Psychol Res Behav Manag. 2022;15:103-110. [CrossRef] [Medline]
  48. Chen D, Liu F, Zhu C, Tai C, Zhang Y, Wang X. The effect of an escape room game on college nursing students’ learning attitude and game flow experiences in teaching safe medication care for the elderly: an intervention educational study. BMC Med Educ. Dec 12, 2023;23(1):945. [CrossRef] [Medline]
  49. EL Machtani EL Idrissi W, Chemsi G, EL Kababi K, Radid M. The impact of serious game on the nursing students’ learning, behavioral engagement, and motivation. Int J Emerg Technol Learn. 2022;17(1):18-35. [CrossRef]
  50. Labrague L. Delegation poker game in nursing. J Nurs Educ. May 2024;63(5):343-344. [CrossRef] [Medline]
  51. Trakeostomi Bakımı. URL: http://trakeostomibakimi.com/ [Accessed 2025-08-08]
  52. Mehraeen E, Dashti M, Mirzapour P, et al. Serious games in nursing education: a systematic review of current evidence. International Journal of Africa Nursing Sciences. 2025;22:100838. [CrossRef]
  53. Dankbaar M. Serious games and blended learning; effects on performance and motivation in medical education. Perspect Med Educ. Feb 2017;6(1):58-60. [CrossRef] [Medline]
  54. Oestreich JH, Guy JW. Game-based learning in pharmacy education. Pharmacy (Basel). Jan 6, 2022;10(1):11. [CrossRef] [Medline]
  55. Chang CY, Chung MH, Yang JC. Facilitating nursing students’ skill training in distance education via online game-based learning with the watch-summarize-question approach during the COVID-19 pandemic: a quasi-experimental study. Nurse Educ Today. Feb 2022;109:105256. [CrossRef] [Medline]
  56. Jossan KS, Gauthier A, Jenkinson J. Cultural implications in the acceptability of game-based learning. Comput Educ. Dec 2021;174:104305. [CrossRef]
  57. McNiesh SG. Cultural norms of clinical simulation in undergraduate nursing education. Glob Qual Nurs Res. 2015;2:2333393615571361. [CrossRef] [Medline]
  58. Kelly MA, Balakrishnan A, Naren K. Cultural considerations in simulation-based education. Asia Pac Scholar. Sep 4, 2018;3(3):1-4. [CrossRef]


APIN: Asia-Pacific Islander Nursing
GBL: game-based learning
NOS: Newcastle-Ottawa Scale
PRISMA: Preferred Reporting Items for Systematic Reviews and Meta-Analyses
VR: virtual reality
VRSUCIG: virtual reality sterile urinary catheter insertion game


Edited by Hyochol Ahn, Wen-Wen Li; submitted 31.12.24; peer-reviewed by Afra ÇALIK, Daniel Cunha; final revised version received 08.06.25; accepted 13.06.25; published 11.08.25.

Copyright

© Soleiman Ahmady, Hanie Zehtab Hashemi, Arghavan Afra, Niloofar Attarian, Amir Tabari, Fariba Shabani, Ayoob Molla, Esmaeil Mehraeen. Originally published in the Asian/Pacific Island Nursing Journal (https://apinj.jmir.org), 11.8.2025.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work, first published in the Asian/Pacific Island Nursing Journal, is properly cited. The complete bibliographic information, a link to the original publication on https://apinj.jmir.org, as well as this copyright and license information must be included.