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  <front>
    <journal-meta>
      <journal-id journal-id-type="publisher-id">JMIR</journal-id>
      <journal-id journal-id-type="nlm-ta">Asian Pac Isl Nurs J</journal-id>
      <journal-title>Asian/Pacific Island Nursing Journal</journal-title>
      <issn pub-type="epub">2373-6658</issn>
      <publisher>
        <publisher-name>JMIR Publications</publisher-name>
        <publisher-loc>Toronto, Canada</publisher-loc>
      </publisher>
    </journal-meta>
    <article-meta>
      <article-id pub-id-type="publisher-id">v8i1e60116</article-id>
      <article-id pub-id-type="pmid">39047286</article-id>
      <article-id pub-id-type="doi">10.2196/60116</article-id>
      <article-categories>
        <subj-group subj-group-type="heading">
          <subject>Viewpoint</subject>
        </subj-group>
        <subj-group subj-group-type="article-type">
          <subject>Viewpoint</subject>
        </subj-group>
      </article-categories>
      <title-group>
        <article-title>Centralized Pump Monitoring System: Perception on Utility and Workflows by Nurses in a Tertiary Hospital</article-title>
      </title-group>
      <contrib-group>
        <contrib contrib-type="editor">
          <name>
            <surname>Ahn</surname>
            <given-names>Hyochol</given-names>
          </name>
        </contrib>
      </contrib-group>
      <contrib-group>
        <contrib contrib-type="reviewer">
          <name>
            <surname>Zhang</surname>
            <given-names>Yuqi</given-names>
          </name>
        </contrib>
        <contrib contrib-type="reviewer">
          <name>
            <surname>Toma</surname>
            <given-names>Milan</given-names>
          </name>
        </contrib>
      </contrib-group>
      <contrib-group>
        <contrib id="contrib1" contrib-type="author" equal-contrib="yes">
          <name name-style="western">
            <surname>Chindamorragot</surname>
            <given-names>Naruemol</given-names>
          </name>
          <degrees>BSN</degrees>
          <xref rid="aff1" ref-type="aff">1</xref>
          <ext-link ext-link-type="orcid">https://orcid.org/0009-0000-8116-1989</ext-link>
        </contrib>
        <contrib id="contrib2" contrib-type="author" corresp="yes" equal-contrib="yes">
          <name name-style="western">
            <surname>Suitthimeathegorn</surname>
            <given-names>Orawan</given-names>
          </name>
          <degrees>BPharm, PhD</degrees>
          <xref rid="aff2" ref-type="aff">2</xref>
          <address>
            <institution>Medical Affairs</institution>
            <institution>Terumo Asia Holdings Pte. Ltd.</institution>
            <addr-line>300 Beach Road</addr-line>
            <addr-line>#37-01 The Concourse</addr-line>
            <addr-line>Singapore, 199555</addr-line>
            <country>Singapore</country>
            <phone>65 92991056</phone>
            <fax>65 62942329</fax>
            <email>orawan_suitthimeathegorn@terumo.co.jp</email>
          </address>
          <ext-link ext-link-type="orcid">https://orcid.org/0009-0008-1982-3847</ext-link>
        </contrib>
        <contrib id="contrib3" contrib-type="author" equal-contrib="yes">
          <name name-style="western">
            <surname>Garg</surname>
            <given-names>Amit</given-names>
          </name>
          <degrees>MD, PhD</degrees>
          <xref rid="aff2" ref-type="aff">2</xref>
          <ext-link ext-link-type="orcid">https://orcid.org/0000-0002-6599-4910</ext-link>
        </contrib>
      </contrib-group>
      <aff id="aff1">
        <label>1</label>
        <institution>Nursing Department</institution>
        <institution>Bangkok Hospital Sanamchan</institution>
        <addr-line>Nakhon Pathom</addr-line>
        <country>Thailand</country>
      </aff>
      <aff id="aff2">
        <label>2</label>
        <institution>Medical Affairs</institution>
        <institution>Terumo Asia Holdings Pte. Ltd.</institution>
        <addr-line>Singapore</addr-line>
        <country>Singapore</country>
      </aff>
      <author-notes>
        <corresp>Corresponding Author: Orawan Suitthimeathegorn <email>orawan_suitthimeathegorn@terumo.co.jp</email></corresp>
      </author-notes>
      <pub-date pub-type="collection">
        <year>2024</year>
      </pub-date>
      <pub-date pub-type="epub">
        <day>24</day>
        <month>7</month>
        <year>2024</year>
      </pub-date>
      <volume>8</volume>
      <elocation-id>e60116</elocation-id>
      <history>
        <date date-type="received">
          <day>3</day>
          <month>5</month>
          <year>2024</year>
        </date>
        <date date-type="rev-request">
          <day>26</day>
          <month>5</month>
          <year>2024</year>
        </date>
        <date date-type="rev-recd">
          <day>10</day>
          <month>6</month>
          <year>2024</year>
        </date>
        <date date-type="accepted">
          <day>18</day>
          <month>6</month>
          <year>2024</year>
        </date>
      </history>
      <copyright-statement>©Naruemol Chindamorragot, Orawan Suitthimeathegorn, Amit Garg. Originally published in the Asian/Pacific Island Nursing Journal (https://apinj.jmir.org), 24.07.2024.</copyright-statement>
      <copyright-year>2024</copyright-year>
      <license license-type="open-access" xlink:href="https://creativecommons.org/licenses/by/4.0/">
        <p>This is an open-access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work, first published in the Asian/Pacific Island Nursing Journal, is properly cited. The complete bibliographic information, a link to the original publication on https://apinj.jmir.org, as well as this copyright and license information must be included.</p>
      </license>
      <self-uri xlink:href="https://apinj.jmir.org/2024/1/e60116" xlink:type="simple"/>
      <abstract>
        <p>Nurses play a key role in providing in-hospital care to patients. Worldwide, there has been a shortage of nursing staff, putting enormous strain on the existing nursing workforce physically and mentally. A vicious cycle of demanding workplaces exacerbated by perennial shortages leads to attrition and high staff turnover. A centralized, automated infusion pump monitoring system optimizes and augments nurses’ performance in the hospital by cutting down on nurse visits to the patient’s bedside for every matter, whether significant or insignificant. This viewpoint intends to highlight that by filtering out the noise effectively, nurses can focus on improving patient outcome–led interventions and enhancing the quality of care.</p>
      </abstract>
      <kwd-group>
        <kwd>infusion management</kwd>
        <kwd>nurse efficiency</kwd>
        <kwd>pump monitoring system</kwd>
        <kwd>nurse attrition</kwd>
      </kwd-group>
    </article-meta>
  </front>
  <body>
    <sec sec-type="introduction">
      <title>Introduction</title>
      <p>A centralized, automated infusion pump monitoring system (PMS) is a dynamic mechanism that integrates multiple infusion pumps into a central location, such as a nurse station. By generating alerts, infusion pumps with drug libraries from dose error-reduction systems can warn nursing staff about potential prescribing, calculation, and programming errors. The pumps are equipped with hard limits (ie, disallow bypass and prevent the start of the infusion) or soft limits (ie, warn of outside range parameters but permit users to start the infusion). Drug libraries can be customized according to institutional needs and can be classified based on care areas, specific patient groups, or body weight configurations. The system can help improve patient safety, comfort, and outcomes by ensuring accurate and timely administration of treatments and preventing treatment-related adverse events [<xref ref-type="bibr" rid="ref1">1</xref>].</p>
      <p>This viewpoint focuses on nursing challenges in general wards, the PMS, and the key outcomes from a survey conducted at a multispecialty hospital in Thailand.</p>
    </sec>
    <sec>
      <title>Nursing Challenges in General Wards and PMS Utility</title>
      <p>In a general ward, patients are generally conscious, and the alarm originating from infusion pumps may disturb patients, create unwanted anxiety, and incur additional nurse visits to the patient’s bedside [<xref ref-type="bibr" rid="ref2">2</xref>,<xref ref-type="bibr" rid="ref3">3</xref>]. Responding to each alert and distress call warrants nurse visits for visual checks, which is time-consuming and physically demanding and enhances cognitive stress [<xref ref-type="bibr" rid="ref2">2</xref>,<xref ref-type="bibr" rid="ref3">3</xref>]. This was also found in the survey, which is discussed later. Nursing as a profession is beset with a stressful environment [<xref ref-type="bibr" rid="ref4">4</xref>-<xref ref-type="bibr" rid="ref7">7</xref>]. The exhaustion is both physical and mental. Work exhaustion compounded by the stressful job of handling emergencies and responding to distress calls and alarms for multiple patients in a general ward could take a heavy toll on the state of the personal health of nurses. We have demonstrated the state of affairs in a hospital’s general ward, whereby a nurse has to manage multiple patients. If the process is manual, it leads to physical exertion, stress, and exhaustion. As illustrated in the left-hand side of <xref rid="figure1" ref-type="fig">Figure 1</xref>, a nurse makes an investigative visit to the patient’s bed upon registering distress calls (orange arrow) and then returns to the central station (black arrow). After finding a solution, the nurse makes another visit to the patient’s bed and administers remedial measures (gray arrow). However, if a ward is equipped with a PMS, as illustrated on the right-hand side of <xref rid="figure1" ref-type="fig">Figure 1</xref>, the nurse can identify the problem on the centralized monitor (eg, blockade) and solve the issue in a single visit. Therefore, the additional steps for each patient call are eliminated, resulting in less physical effort and exhaustion. Staff burnout impacts organizational performance, patient safety, and health outcomes if appropriate interventions are not undertaken.</p>
      <fig id="figure1" position="float">
        <label>Figure 1</label>
        <caption>
          <p>In general wards, the use of a PMS with an infusion system reduces nurse’s movement and improves workflow efficiency in comparison to without a PMS. PMS: pump monitoring system.</p>
        </caption>
        <graphic xlink:href="apinj_v8i1e60116_fig1.png" alt-version="no" mimetype="image" position="float" xlink:type="simple"/>
      </fig>
      <fig id="figure2" position="float">
        <label>Figure 2</label>
        <caption>
          <p>PMS benefits to the stakeholders in care delivery. Workflow efficiency improvement, better decision-making, and closer patient monitoring result in greater patient safety standards. AE: adverse event; IV: intravenous; PMS: pump monitoring system.</p>
        </caption>
        <graphic xlink:href="apinj_v8i1e60116_fig2.png" alt-version="no" mimetype="image" position="float" xlink:type="simple"/>
      </fig>
    </sec>
    <sec>
      <title>Impact of a PMS on Nurses’ Workflow in Hospitals</title>
      <p>A PMS is critical in reducing physical movements with the centralized display of the infusion status on the monitor. Regardless of the clinical settings, a PMS prevents undetected infusion errors, such as incorrect doses or infusion data, and facilitates care coordination and collaboration with other health care professionals by sharing intravenous infusion data and alerts through the network and health information systems [<xref ref-type="bibr" rid="ref8">8</xref>]. Several benefits have been attributed to the PMS, benefitting all the stakeholders—patients, nurses, and care providers—in the health care ecosystem, as shown in <xref rid="figure2" ref-type="fig">Figure 2</xref>.</p>
    </sec>
    <sec>
      <title>Key Outcomes of the Nurse Survey in a General Ward</title>
      <sec>
        <title>Overview</title>
        <p>We present the survey conducted in Bangkok Hospital Sanamchan (210 beds), situated in Mueang District, Nakhon Pathom Province, Thailand. A cross-sectional survey of the 91 nurses working in the general ward was conducted in October 2023, and they were asked to report their feedback on a 7-point Likert scale. We manually explained the presented questions to the nurses, and they submitted their responses in complete privacy on a paper-based system. The key objectives of the survey were as follows:</p>
        <list list-type="bullet">
          <list-item>
            <p>To evaluate the work efficiency of nursing staff after the implementation of a PMS. The efficiency parameters included reducing the frequency of entering patients’ rooms to check pump status, decreasing the number of nurse calls, and other related factors.</p>
          </list-item>
          <list-item>
            <p>To examine the potential impact of the PMS on nursing workflow, work planning, and patient recovery.</p>
          </list-item>
        </list>
        <p>The response scheme was as follows: 1=“Strongly disagree,” 2=“Disagree,” 3=“Somewhat disagree,” 4=“Neither agree OR disagree,” 5=“Somewhat agree,” 6=“Agree,” and 7=“Strongly agree.” The responses were compiled in Microsoft Excel, and an inferential analysis was applied to the data. The results were interpreted using the central tendency analysis of mean and plotted in an intuitive graphical form. The full survey is shown in <xref ref-type="supplementary-material" rid="app1">Multimedia Appendix 1</xref>.</p>
      </sec>
      <sec>
        <title>Ethical Considerations</title>
        <p>No institutional review board approval was sought. This is because this study focuses solely on gathering feedback to gain perception on the use of the PMS software, similar to a product use survey. Participants were not selected according to any pattern or priority; instead, all nurses working in the general ward were chosen to respond. The purpose of the survey is to evaluate the satisfaction and effectiveness of the PMS software after its installation in the general ward. The survey is entirely anonymous, with no personal details and identities disclosed in any documentation, and it involves no patient data. All participants were fully informed about the survey’s purpose and provided their consent. As the survey seeks to gather feedback on the software product before and after its implementation, without involving patient data or interventions, it falls outside the scope of requiring institutional review board approval.</p>
      </sec>
      <sec>
        <title>Impact of the PMS on the Work Planning of Nurses</title>
        <p>The respondents stated that the PMS reduces the number of visits to the patient’s room to check on the pump's operating status (85/91, 93%), and they felt that their anxiety was reduced due to fewer calls from the patient’s room (83/91, 91%). A similar level of response (82/91, 90%) was received on the decrease in the number of calls from patients’ rooms due to PMS adoption (<xref rid="figure3" ref-type="fig">Figure 3</xref>).</p>
        <fig id="figure3" position="float">
          <label>Figure 3</label>
          <caption>
            <p>PMS impact on work planning and efficiency. PMS: pump monitoring system.</p>
          </caption>
          <graphic xlink:href="apinj_v8i1e60116_fig3.png" alt-version="no" mimetype="image" position="float" xlink:type="simple"/>
        </fig>
      </sec>
      <sec>
        <title>Impact of the PMS on Work Efficiency</title>
        <p>The respondents reported that the PMS helps improve work efficiency (88/91, 97%), helps in work schedule planning to ensure patient safety (91/91, 100%), and saves time (91/91, 100%; <xref rid="figure4" ref-type="fig">Figure 4</xref>).</p>
        <fig id="figure4" position="float">
          <label>Figure 4</label>
          <caption>
            <p>Work efficiency with PMS integration in the workflow. PMS: pump monitoring system.</p>
          </caption>
          <graphic xlink:href="apinj_v8i1e60116_fig4.png" alt-version="no" mimetype="image" position="float" xlink:type="simple"/>
        </fig>
      </sec>
      <sec>
        <title>Impact of PMS Integration on Patient Recovery</title>
        <p>Approximately 95% (86/91) of respondents stated that use of a PMS in a patient’s room increases patient and family member satisfaction. Meanwhile, 84% (76/91) of respondents indicated that the PMS may help improve patient recovery. Approximately 96% (87/91) of respondents mentioned that patients sleep better due to the lack of disruption and fewer nursing staff visits to the room, making the patient care area quieter (<xref rid="figure5" ref-type="fig">Figure 5</xref>).</p>
        <p>The findings outline 2 broad attributes: PMS’s benefits and its impact on improving patient outcomes. <xref rid="figure3" ref-type="fig">Figures 3</xref> and <xref rid="figure4" ref-type="fig">4</xref> show that workflow planning and efficiency are enhanced with the PMS, whereas <xref rid="figure5" ref-type="fig">Figure 5</xref> shows that patient recovery is possibly boosted due to better rest, fewer sleep disturbances, and less care delivery–generated stress.</p>
        <p>We would like to highlight that large-scale studies in diverse settings are needed to reproduce and replicate the results we have obtained. These outcomes must be viewed from an indicative perspective and may not be representative phenomena of PMSs across all health care systems.</p>
        <fig id="figure5" position="float">
          <label>Figure 5</label>
          <caption>
            <p>Effect of the PMS on patient recovery. PMS: pump monitoring system.</p>
          </caption>
          <graphic xlink:href="apinj_v8i1e60116_fig5.png" alt-version="no" mimetype="image" position="float" xlink:type="simple"/>
        </fig>
      </sec>
    </sec>
    <sec>
      <title>Critical Implications for Patient Care</title>
      <p>The survey findings point to the issue of nurse distraction and continuous disengagement from the involved tasks when any patient distress signals are heard in a general ward setting. The resultant anxiety and immediate dash to check on the patient’s status has 2 significant adverse impacts: the mental and physical health of the nurses. The general ward is relatively spread out, and the diverse patient mix makes nursing care more strenuous. While there are many established benefits of PMS models, we would like to draw our implications from the outcomes of this survey as a more pragmatic approach.</p>
      <p>The most apparent benefits of the PMS for the nursing staff are the ability and flexibility to plan work schedules in a more organized and efficient way, reduce multiple movements, and discharge patient care duties with less exhaustion and greater focus [<xref ref-type="bibr" rid="ref8">8</xref>]. Also, the PMS ensures no unnecessary patient distress, sleep disturbances, and bedside environment instability. The resultant effect on patient recovery and outcomes is compounded due to more efficient nursing care in the hospital [<xref ref-type="bibr" rid="ref9">9</xref>,<xref ref-type="bibr" rid="ref10">10</xref>].</p>
      <p>PMS application requires an integrated, multimodal approach to render efficiencies and deliver benefits at scale. This includes infrastructure, training, network, interoperability of the health information systems, and monitoring with a collective approach to align with the goals of enhancing the quality of patient care.</p>
    </sec>
    <sec>
      <title>Future Trends</title>
      <p>Technology and data-driven innovation have resulted in the development of PMS models to advance patient care faster. Also, with PMS integration into electronic health records, more and more real-world data are being generated, resulting in more advanced PMS models [<xref ref-type="bibr" rid="ref11">11</xref>,<xref ref-type="bibr" rid="ref12">12</xref>].</p>
      <p>To achieve an interconnected, interoperational ecosystem, the wireless connectivity of PMS; image recognition—barcode medication administration and radio-frequency identification; computerized prescriber order entry; and integration into electronic health records seem to be the next steps forward. Each of these technologies exists and is being used in hospitals, but these may be operated in “silos” and not as integrated, interconnected ecosystems. It is envisaged that these technologies, when working in unison as a cohesive force, can provide auto-programming and auto-documentation; clinical decision support; clinical surveillance; and an alert mechanism that highlights critical situations demanding immediate intervention and communicates to the health care professional who is best positioned to solve the problem.</p>
    </sec>
    <sec>
      <title>Conclusion</title>
      <p>A PMS enhances the nursing staff’s functional and physical capabilities during their workflows, enabling better performance within the hospital environment. A more systematic approach and reduced exhaustion contribute to fewer nursing care errors. As a result, the quality of patient care improves, leading to better care outcomes. Eventually, all the stakeholders in the health care ecosystem—patients, clinicians, and nursing staff; the health care system itself; and society would benefit at different levels.</p>
    </sec>
  </body>
  <back>
    <app-group>
      <supplementary-material id="app1">
        <label>Multimedia Appendix 1</label>
        <p>Pump monitoring system (PMS) use survey.</p>
        <media xlink:href="apinj_v8i1e60116_app1.docx" xlink:title="DOCX File , 37 KB"/>
      </supplementary-material>
    </app-group>
    <glossary>
      <title>Abbreviations</title>
      <def-list>
        <def-item>
          <term id="abb1">PMS</term>
          <def>
            <p>pump monitoring system</p>
          </def>
        </def-item>
      </def-list>
    </glossary>
    <ack>
      <p>Medical writing support for the manuscript was provided by Dr Suchitra Kataria from Mélange Communications Pte Ltd, Singapore.</p>
    </ack>
    <notes>
      <sec>
        <title>Data Availability</title>
        <p>The survey data can be made available upon a reasonable request to the corresponding author.</p>
      </sec>
    </notes>
    <fn-group>
      <fn fn-type="con">
        <p>All the authors contributed equally to conceptualizing, formal analysis, project administration, writing review, and editing. NC led the hospital survey and analysis at Bangkok Hospital Sanamchan.</p>
      </fn>
      <fn fn-type="conflict">
        <p>OS and AG are employees of Terumo Asia Holdings Pte Ltd, Singapore. NC has no conflicts of interest to declare.</p>
      </fn>
    </fn-group>
    <ref-list>
      <ref id="ref1">
        <label>1</label>
        <nlm-citation citation-type="confproc">
          <person-group person-group-type="author">
            <name name-style="western">
              <surname>Sangeetha</surname>
              <given-names>K</given-names>
            </name>
            <name name-style="western">
              <surname>Vishnuraja</surname>
              <given-names>P</given-names>
            </name>
            <name name-style="western">
              <surname>Dinesh</surname>
              <given-names>S</given-names>
            </name>
            <name name-style="western">
              <surname>Gokul Anandh</surname>
              <given-names>VS</given-names>
            </name>
            <name name-style="western">
              <surname>Hariprakash</surname>
              <given-names>K</given-names>
            </name>
          </person-group>
          <article-title>Intravenous fluid monitoring system using IoT</article-title>
          <year>2022</year>
          <month>7</month>
          <day>23</day>
          <conf-name>International Conference on Mobile Computing and Sustainable Informatics (ICMCSI 2021)</conf-name>
          <conf-date>January 29-30, 2021</conf-date>
          <conf-loc>Kirtipur, Nepal</conf-loc>
          <fpage>867</fpage>
          <lpage>871</lpage>
          <pub-id pub-id-type="doi">10.1007/978-981-16-1866-6_66</pub-id>
        </nlm-citation>
      </ref>
      <ref id="ref2">
        <label>2</label>
        <nlm-citation citation-type="journal">
          <person-group person-group-type="author">
            <name name-style="western">
              <surname>Waterson</surname>
              <given-names>J</given-names>
            </name>
            <name name-style="western">
              <surname>Bedner</surname>
              <given-names>A</given-names>
            </name>
          </person-group>
          <article-title>Types and frequency of infusion pump alarms and infusion-interruption to infusion-recovery times for critical short half-life infusions: retrospective data analysis</article-title>
          <source>JMIR Hum Factors</source>
          <year>2019</year>
          <month>08</month>
          <day>12</day>
          <volume>6</volume>
          <issue>3</issue>
          <fpage>e14123</fpage>
          <comment>
            <ext-link ext-link-type="uri" xlink:type="simple" xlink:href="https://humanfactors.jmir.org/2019/3/e14123/"/>
          </comment>
          <pub-id pub-id-type="doi">10.2196/14123</pub-id>
          <pub-id pub-id-type="medline">31407667</pub-id>
          <pub-id pub-id-type="pii">v6i3e14123</pub-id>
          <pub-id pub-id-type="pmcid">PMC6709565</pub-id>
        </nlm-citation>
      </ref>
      <ref id="ref3">
        <label>3</label>
        <nlm-citation citation-type="journal">
          <person-group person-group-type="author">
            <name name-style="western">
              <surname>Sendelbach</surname>
              <given-names>S</given-names>
            </name>
            <name name-style="western">
              <surname>Funk</surname>
              <given-names>M</given-names>
            </name>
          </person-group>
          <article-title>Alarm fatigue: a patient safety concern</article-title>
          <source>AACN Adv Crit Care</source>
          <year>2013</year>
          <volume>24</volume>
          <issue>4</issue>
          <fpage>378</fpage>
          <lpage>86; quiz 387</lpage>
          <pub-id pub-id-type="doi">10.1097/NCI.0b013e3182a903f9</pub-id>
          <pub-id pub-id-type="medline">24153215</pub-id>
          <pub-id pub-id-type="pii">01256961-201310000-00009</pub-id>
        </nlm-citation>
      </ref>
      <ref id="ref4">
        <label>4</label>
        <nlm-citation citation-type="journal">
          <person-group person-group-type="author">
            <name name-style="western">
              <surname>Suptitz Carneiro</surname>
              <given-names>A</given-names>
            </name>
            <name name-style="western">
              <surname>Andolhe</surname>
              <given-names>R</given-names>
            </name>
            <name name-style="western">
              <surname>de Lima Dalmolin</surname>
              <given-names>G</given-names>
            </name>
            <name name-style="western">
              <surname>de Magalhães</surname>
              <given-names>Ana Maria Müller</given-names>
            </name>
            <name name-style="western">
              <surname>de Souza Magnago</surname>
              <given-names>TSB</given-names>
            </name>
            <name name-style="western">
              <surname>Soares Arrial</surname>
              <given-names>T</given-names>
            </name>
          </person-group>
          <article-title>Occupational stress, burnout and patient safety culture among workers from critical care and non critical care units in a hospital in Brazil</article-title>
          <source>Intensive Crit Care Nurs</source>
          <year>2021</year>
          <month>04</month>
          <volume>63</volume>
          <fpage>102978</fpage>
          <pub-id pub-id-type="doi">10.1016/j.iccn.2020.102978</pub-id>
          <pub-id pub-id-type="medline">33257217</pub-id>
          <pub-id pub-id-type="pii">S0964-3397(20)30181-6</pub-id>
        </nlm-citation>
      </ref>
      <ref id="ref5">
        <label>5</label>
        <nlm-citation citation-type="journal">
          <person-group person-group-type="author">
            <name name-style="western">
              <surname>Asefzadeh</surname>
              <given-names>S</given-names>
            </name>
            <name name-style="western">
              <surname>Kalhor</surname>
              <given-names>R</given-names>
            </name>
            <name name-style="western">
              <surname>Tir</surname>
              <given-names>M</given-names>
            </name>
          </person-group>
          <article-title>Patient safety culture and job stress among nurses in Mazandaran, Iran</article-title>
          <source>Electron Physician</source>
          <year>2017</year>
          <month>12</month>
          <volume>9</volume>
          <issue>12</issue>
          <fpage>6010</fpage>
          <lpage>6016</lpage>
          <comment>
            <ext-link ext-link-type="uri" xlink:type="simple" xlink:href="https://europepmc.org/abstract/MED/29560154"/>
          </comment>
          <pub-id pub-id-type="doi">10.19082/6010</pub-id>
          <pub-id pub-id-type="medline">29560154</pub-id>
          <pub-id pub-id-type="pii">epj-09-6010</pub-id>
          <pub-id pub-id-type="pmcid">PMC5843428</pub-id>
        </nlm-citation>
      </ref>
      <ref id="ref6">
        <label>6</label>
        <nlm-citation citation-type="journal">
          <person-group person-group-type="author">
            <name name-style="western">
              <surname>Li</surname>
              <given-names>X</given-names>
            </name>
            <name name-style="western">
              <surname>Jiang</surname>
              <given-names>T</given-names>
            </name>
            <name name-style="western">
              <surname>Sun</surname>
              <given-names>J</given-names>
            </name>
            <name name-style="western">
              <surname>Shi</surname>
              <given-names>L</given-names>
            </name>
            <name name-style="western">
              <surname>Liu</surname>
              <given-names>J</given-names>
            </name>
          </person-group>
          <article-title>The relationship between occupational stress, job burnout and quality of life among surgical nurses in Xinjiang, China</article-title>
          <source>BMC Nurs</source>
          <year>2021</year>
          <month>09</month>
          <day>27</day>
          <volume>20</volume>
          <issue>1</issue>
          <fpage>181</fpage>
          <comment>
            <ext-link ext-link-type="uri" xlink:type="simple" xlink:href="https://bmcnurs.biomedcentral.com/articles/10.1186/s12912-021-00703-2"/>
          </comment>
          <pub-id pub-id-type="doi">10.1186/s12912-021-00703-2</pub-id>
          <pub-id pub-id-type="medline">34579710</pub-id>
          <pub-id pub-id-type="pii">10.1186/s12912-021-00703-2</pub-id>
          <pub-id pub-id-type="pmcid">PMC8477556</pub-id>
        </nlm-citation>
      </ref>
      <ref id="ref7">
        <label>7</label>
        <nlm-citation citation-type="journal">
          <person-group person-group-type="author">
            <name name-style="western">
              <surname>Chatzigianni</surname>
              <given-names>D</given-names>
            </name>
            <name name-style="western">
              <surname>Tsounis</surname>
              <given-names>A</given-names>
            </name>
            <name name-style="western">
              <surname>Markopoulos</surname>
              <given-names>N</given-names>
            </name>
            <name name-style="western">
              <surname>Sarafis</surname>
              <given-names>P</given-names>
            </name>
          </person-group>
          <article-title>Occupational stress experienced by nurses working in a Greek regional hospital: a cross-sectional study</article-title>
          <source>Iran J Nurs Midwifery Res</source>
          <year>2018</year>
          <volume>23</volume>
          <issue>6</issue>
          <fpage>450</fpage>
          <lpage>457</lpage>
          <comment>
            <ext-link ext-link-type="uri" xlink:type="simple" xlink:href="http://www.ijnmrjournal.net/article.asp?issn=1735-9066;year=2018;volume=23;issue=6;spage=450;epage=457;aulast=Chatzigianni"/>
          </comment>
          <pub-id pub-id-type="doi">10.4103/ijnmr.IJNMR_120_17</pub-id>
          <pub-id pub-id-type="medline">30386395</pub-id>
          <pub-id pub-id-type="pii">IJNMR-23-450</pub-id>
          <pub-id pub-id-type="pmcid">PMC6178576</pub-id>
        </nlm-citation>
      </ref>
      <ref id="ref8">
        <label>8</label>
        <nlm-citation citation-type="journal">
          <person-group person-group-type="author">
            <name name-style="western">
              <surname>Giuliano</surname>
              <given-names>KK</given-names>
            </name>
            <name name-style="western">
              <surname>Mahuren</surname>
              <given-names>RS</given-names>
            </name>
            <name name-style="western">
              <surname>Balyeat</surname>
              <given-names>J</given-names>
            </name>
          </person-group>
          <article-title>Data-based program management of system-wide IV smart pump integration</article-title>
          <source>Am J Health Syst Pharm</source>
          <year>2024</year>
          <month>01</month>
          <day>01</day>
          <volume>81</volume>
          <issue>1</issue>
          <fpage>e30</fpage>
          <lpage>e36</lpage>
          <comment>
            <ext-link ext-link-type="uri" xlink:type="simple" xlink:href="https://europepmc.org/abstract/MED/37804239"/>
          </comment>
          <pub-id pub-id-type="doi">10.1093/ajhp/zxad245</pub-id>
          <pub-id pub-id-type="medline">37804239</pub-id>
          <pub-id pub-id-type="pii">7296483</pub-id>
          <pub-id pub-id-type="pmcid">PMC10727471</pub-id>
        </nlm-citation>
      </ref>
      <ref id="ref9">
        <label>9</label>
        <nlm-citation citation-type="journal">
          <person-group person-group-type="author">
            <name name-style="western">
              <surname>Doesburg</surname>
              <given-names>F</given-names>
            </name>
            <name name-style="western">
              <surname>Cnossen</surname>
              <given-names>F</given-names>
            </name>
            <name name-style="western">
              <surname>Dieperink</surname>
              <given-names>W</given-names>
            </name>
            <name name-style="western">
              <surname>Bult</surname>
              <given-names>W</given-names>
            </name>
            <name name-style="western">
              <surname>de Smet</surname>
              <given-names>AM</given-names>
            </name>
            <name name-style="western">
              <surname>Touw</surname>
              <given-names>D</given-names>
            </name>
            <name name-style="western">
              <surname>Nijsten</surname>
              <given-names>MW</given-names>
            </name>
          </person-group>
          <article-title>Improved usability of a multi-infusion setup using a centralized control interface: a task-based usability test</article-title>
          <source>PLoS One</source>
          <year>2017</year>
          <month>8</month>
          <day>11</day>
          <volume>12</volume>
          <issue>8</issue>
          <fpage>e0183104</fpage>
          <comment>
            <ext-link ext-link-type="uri" xlink:type="simple" xlink:href="https://dx.plos.org/10.1371/journal.pone.0183104"/>
          </comment>
          <pub-id pub-id-type="doi">10.1371/journal.pone.0183104</pub-id>
          <pub-id pub-id-type="medline">28800617</pub-id>
          <pub-id pub-id-type="pii">PONE-D-17-15909</pub-id>
          <pub-id pub-id-type="pmcid">PMC5553772</pub-id>
        </nlm-citation>
      </ref>
      <ref id="ref10">
        <label>10</label>
        <nlm-citation citation-type="journal">
          <person-group person-group-type="author">
            <name name-style="western">
              <surname>Sutherland</surname>
              <given-names>A</given-names>
            </name>
            <name name-style="western">
              <surname>Jones</surname>
              <given-names>MD</given-names>
            </name>
            <name name-style="western">
              <surname>Howlett</surname>
              <given-names>M</given-names>
            </name>
            <name name-style="western">
              <surname>Arenas-Lopez</surname>
              <given-names>S</given-names>
            </name>
            <name name-style="western">
              <surname>Patel</surname>
              <given-names>A</given-names>
            </name>
            <name name-style="western">
              <surname>Franklin</surname>
              <given-names>BD</given-names>
            </name>
          </person-group>
          <article-title>Developing strategic recommendations for implementing smart pumps in advanced healthcare systems to improve intravenous medication safety</article-title>
          <source>Drug Saf</source>
          <year>2022</year>
          <month>08</month>
          <volume>45</volume>
          <issue>8</issue>
          <fpage>881</fpage>
          <lpage>889</lpage>
          <comment>
            <ext-link ext-link-type="uri" xlink:type="simple" xlink:href="https://europepmc.org/abstract/MED/35838875"/>
          </comment>
          <pub-id pub-id-type="doi">10.1007/s40264-022-01203-1</pub-id>
          <pub-id pub-id-type="medline">35838875</pub-id>
          <pub-id pub-id-type="pii">10.1007/s40264-022-01203-1</pub-id>
          <pub-id pub-id-type="pmcid">PMC9283846</pub-id>
        </nlm-citation>
      </ref>
      <ref id="ref11">
        <label>11</label>
        <nlm-citation citation-type="journal">
          <person-group person-group-type="author">
            <name name-style="western">
              <surname>Mao</surname>
              <given-names>Z</given-names>
            </name>
            <name name-style="western">
              <surname>Liu</surname>
              <given-names>C</given-names>
            </name>
            <name name-style="western">
              <surname>Li</surname>
              <given-names>Q</given-names>
            </name>
            <name name-style="western">
              <surname>Cui</surname>
              <given-names>Y</given-names>
            </name>
            <name name-style="western">
              <surname>Zhou</surname>
              <given-names>F</given-names>
            </name>
          </person-group>
          <article-title>Intelligent intensive care unit: current and future trends</article-title>
          <source>Intensive Care Res</source>
          <year>2023</year>
          <month>05</month>
          <day>16</day>
          <fpage>1</fpage>
          <lpage>7</lpage>
          <comment>
            <ext-link ext-link-type="uri" xlink:type="simple" xlink:href="https://europepmc.org/abstract/MED/37360311"/>
          </comment>
          <pub-id pub-id-type="doi">10.1007/s44231-023-00036-5</pub-id>
          <pub-id pub-id-type="medline">37360311</pub-id>
          <pub-id pub-id-type="pii">36</pub-id>
          <pub-id pub-id-type="pmcid">PMC10186295</pub-id>
        </nlm-citation>
      </ref>
      <ref id="ref12">
        <label>12</label>
        <nlm-citation citation-type="web">
          <article-title>ISMP guidelines for optimizing safe implementation and use of smart infusion pumps</article-title>
          <source>Institute for Safe Medication Practices (ISMP)</source>
          <year>2020</year>
          <access-date>2024-07-05</access-date>
          <comment>
            <ext-link ext-link-type="uri" xlink:type="simple" xlink:href="https://www.ismp.org/guidelines/safe-implementation-and-use-smart-pumps">https://www.ismp.org/guidelines/safe-implementation-and-use-smart-pumps</ext-link>
          </comment>
        </nlm-citation>
      </ref>
    </ref-list>
  </back>
</article>
